Extended Data Fig. 7: Age-dependent transcriptomic dynamics are specific to human imGCs.
From: Molecular landscapes of human hippocampal immature neurons across lifespan
a-c, In contrast to human imGCs (Fig. 3f), pseudo-age cell alignment of human mature (a), mouse immature (b), and mouse mature (c) GCs9 shows very little age-related divergence, visualized as scatter plots. Cells were colored by age group. Distribution of cells within each age group on the pseudo-age trajectory is displayed in the density plots (bottom left). See summary plots in Fig. 3g. d, Summary plot comparing pseudo-age alignment (y-axis) of mouse mGCs to real age groups (x-axis), with each mGC of the different age groups plotted as a data point in the background. Data points are fitted with loess fitting (lines) with 95% confidence interval (grey shades). Pearson’s r was measured for correlation of pseudo-age and real-age groups. Mouse datasets9 at prenatal (E16.5), neonatal (P0), or early postnatal (P5) stages do not contain mGC populations.
