Extended Data Fig. 4: CA1 context-selective neurons are conjunctive and not movement related.
From: Prefrontal feature representations drive memory recall
a-b, sample traces of 3 context selective neurons (z-scored, orange) overlaid with lick rate (blue, in a) and speed (blue, in b), showing no significant correlation to motor activity (black dashed lines indicate onset of contexts). Context selective neurons are distributed evenly in the field of view (red: reward ensemble, black: aversive ensemble cell centroids) with low correlations (z axis) to lick rates (c), speed (d) and acceleration (e), shown here for a representative mouse. f, feature responsive ensembles exhibit highly generalized activity across all features of the same context, as shown in (g) (Scale; x:1s, y:0.2dF/F). g, Single trial neural trajectories show indiscernible feature trajectories of the same context (similar to Fig. 1h but all trials projected), but divergent across the two contexts (shade of red are reward context feature trials, shades of black are aversive context feature trials) for 3 mice, with variance explained by first 3 PC’s (34%, 28%, 25%)
