Extended Data Fig. 8: Chromosomes in the periphery of the nucleus mis-segregate more frequently independent of identity.
From: Nuclear chromosome locations dictate segregation error frequencies
a,b, Representative still (a) and quantification (b) of the percentage of Cas9-tagged peripheral chromosomes just before mitosis onset (mean ± s.e.m., two-tailed Fisher’s exact test). Only chromosomes in the most outer ring were considered peripheral. b,c, Representative stills (c) and quantification (d) of chr11 mis-segregation rate of LacI-GFP-expressing HT1080 cells containing a LacO array in chr11 (scale bar, 5 μm). Red arrowheads follow a mis-segregating chromosome pair, while white ones follows a properly segregating pair. Experiment was performed in triplicate (mean ± s.e.m., two-tailed Fisher’s exact test).
