Extended Data Fig. 5: Mis-segregation frequency correlates with chromosome organization and organization is similar between cell lines.
From: Nuclear chromosome locations dictate segregation error frequencies
a,b,c,d, Plots comparing aneuploidy percentages after Cpd-5 treatment (see Fig. 1c) in RPE1-hTERT cells to centromere sizes (a), ratio of P- over Q arm sizes (b), chromosome sizes (c), and gene densities (d) (two-tailed Pearson correlation coefficient). e. Quantification of aneuploidy percentages of both X chromosomes in RPE1-hTERT cells after Cpd-5 treatment (mean ± s.e.m., two-tailed Fisher’s exact test, n = 133 cells with an X chromosome aneuploidy). f. Plot comparing aneuploidy percentages after Cpd-5 treatment versus previously determined radial distances (two-tailed Pearson correlation coefficient)37. g,h,i,j,k,l,m, Plots comparing the percentage of LADs per chromosome for indicated cell lines to chromosome size (two-tailed Pearson correlation coefficient).
