Extended Data Fig. 1: Mutations detected in E. gallinarum isolates from SPF NZW × BXSB F1 mice.
From: Within-host evolution of a gut pathobiont facilitates liver translocation
a, Pangenome of eighteen E. gallinarum strains. b, Schematic of the complete genome of E. gallinarum strain EGF1-FE1. c, Number of singleton or shared variants detected in E. gallinarum faecal or liver isolates. d, Functional classes of genes with nonsynonymous mutations or indels. n = 13 genes. e, Relative abundance of liver and faecal E. gallinarum isolates in the faeces of co-colonized SPF C57BL/6 mice. Mice were gavaged with equal doses of EGF1-LV1 and EGF1-FE4 and faecal samples were analysed one week after colonization. n = 6 mice across two independent experiments. Data represent mean ± SEM. Unpaired two-tailed t-test (e). NSY, nonsynonymous SNVs; SYN, synonymous SNVs; Indel, small insertion/deletion variant; Inter, intergenic variant. EG, E. gallinarum.
