Extended Data Fig. 5: cryo-EM map of structural elements of WNT3Ap/LGK974-bound PORCN and pamWNT3Ap-bound PORCN.
From: Mechanisms and inhibition of Porcupine-mediated Wnt acylation
a, The Fourier shell correlation (FSC) curves calculated between the refined structure model and the half map used for refinement (yellow), the other half map (gray) and the full map (blue) of WNT3Ap/LGK974-bound PORCN. b, Density map colored by local resolution estimation using cryoSPARC. c, The major helices of PORCN, WNT3Ap and LGK974. d, The Fourier shell correlation (FSC) curves calculated between the refined structure model and the half map used for refinement (yellow), the other half map (gray) and the full map (blue) of pamWNT3Ap-bound PORCN. e, Density map colored by local resolution estimation using cryoSPARC. f, The major helices of PORCN and pamWNT3Ap.
