Extended Data Fig. 6: The structure of DHHC20 and the structural comparison of PORCN (gray) with the other MBOAT proteins.
From: Mechanisms and inhibition of Porcupine-mediated Wnt acylation
a, The structure of DHHC20. The zinc ions are shown as gray balls. b, The structural comparison with DltB. c, The structural comparison with HHAT. IMP-1575, an HHAT inhibitor, is shown as green sticks. The catalytic H379 of HHAT is shown as sticks. d, The structural comparison with DGAT1. e, The structural comparison with ACAT1. The LGK974 is shown as magenta sticks. Nevanimibe, an ACAT1 inhibitor, is shown as green sticks. The acyl-CoA in the DGAT and ACAT1 is shown as yellow sticks.
