Extended Data Fig. 8: Superimposing the WNT8A-FZD and WNT8A-WLS complexes into the structure of pamWNT3Ap-bound PORCN and the model of WNT3A-bound PORCN.
From: Mechanisms and inhibition of Porcupine-mediated Wnt acylation
a, Superimposing the hairpin 2 of the structure of WNT8A-FZD complex into PORCN-pamWNT3Ap complex. The clash between WNT8A ligand and PORCN is indicated by a dashed circle. b, Superimposing the hairpin 2 of the structure of WNT8A-WLS complex into PORCN-pamWNT3Ap complex. The clash between WNT8A ligand and PORCN is indicated by a dashed circle. PAM, palmitoleic acid (red sticks). c, The predicted structure of WNT3A-bound PORCN. Three hairpins of WNT3A have been indicated. d, Structural comparison of the predicted PORCN structure to the cryo-EM structure (PDB:7URA).
