Extended Data Fig. 9: RNA analysis of NMRK2.
a, Coverage plot of RNA-sequenced reads from heart tissue from 169 heart tissue samples over the gene NMRK2. One individual is a carrier of a 754bp deletion depicted with gray rectangle that includes exon 6 of NMRK2. The RNA-coverage of the carrier (blue) is lower over exon 6 compared to median coverage of non-carriers (green). Shading marks the deleted region. b, Histogram of fraction of RNA-sequenced fragments skipping exon 6 in NMRK2 out of all fragments aligning from the donor site of exon 5 to either acceptor site of exon 6 or exon 7. The median fraction fragments skipping for wild-type individuals is 0.035 and 0.57 for the carrier of the 754bp deletion.
