Extended Data Fig. 9: Characterisation of AdarZα/- Ripk3-/- and AdarZα/- Mlkl-/- Casp8-/- mice.
From: ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation
a, Sections from ileum or jejunum of Adar+/Zα Zbp1+/+ and AdarZα/- Zbp1+/+ or Zbp1Zα1Zα2/Zα1Zα2 mice stained for cleaved caspase-8 (D387) and counterstained with haematoxylin. Scale bars = 100 µm. At least 3 mice per genotype were analysed. b, Numbers (n) and percentages of pups obtained from interbreeding of Adar+/- Ripk3+/- X Adar+/Zα Ripk3+/- mice. c, Number of AdarZα/- Ripk3+/+, AdarZα/- Ripk3+/- or AdarZα/- Ripk3-/- that survived beyond day 2 after birth (> P2). d, Numbers and percentages of pups obtained from interbreeding of Adar+/- Mlkl-/- X Adar+/Zα Mlkl-/- mice. e, Numbers and percentages of pups obtained from interbreeding of Adar+/- Mlkl-/- X Adar Zα/Zα Mlkl-/- mice. f, Numbers and percentages of pups obtained from interbreeding of Adar+/- Mlkl-/- Casp8+/- X Adar+/Zα Mlkl-/- Casp8+/- mice. g, Numbers and percentages of pups obtained from interbreeding of Adar+/- Mlkl-/- Casp8+/- X Adar Zα/Zα Mlkl-/- Casp8+/- mice. h, Number of AdarZα/- Mlkl-/- Casp8+/+, AdarZα/- Mlkl-/- Casp8+/- or AdarZα/- Mlkl-/- Casp8-/- mice that survived beyond day 2 after birth (> P2).
