Extended Data Fig. 4: Characterisation of Adar^Zα/- Zbp1^{Zα1α2/Zα1α2} and Adar^Zα/- Mavs^+/- Zbp1^{Zα1α2/Zα1α2} mice.

a, Percentages of offspring (n = 195) with the indicated genotypes obtained from Adar^+/- Zbp1^{Zα1α2/Zα1α2} X Adar^+/Zα Zbp1^+/Zα1α2 breeding pairs. b, Representative image of a 14 week old Adar^Zα/- Zbp1^{Zα1α2/Zα1α2} mouse and its Adar^+/- Zbp1^{Zα1α2/Zα1α2} littermate. c, Weight in grams (g) of male mice of the indicated genotypes measured weekly from birth till 20 weeks of age. Each data point represents an individual mouse; lines represent a sigmoidal, 4PL fit; P value by two-way ANOVA. d, H&E staining of longitudinal sections of whole intestines from 1 day old mice from the indicated genotypes. Jejunum and ileum are indicated by arrows. Caecum and colon are indicated by a pink and purple line, respectively. Scale bar = 0.2 cm. Red triangles indicate necrotic tissue in caecum and colon. e, RT-qPCR analysis of the indicated ISGs, analysed in whole tissue lysates of lungs and brains of 1 day old pups of the indicated genotypes. f, RT-qPCR analysis of the indicated inflammatory genes, analysed in whole tissue lysates of intestines, lungs and brains of 1 day old pups of the indicated genotypes. Lines in (e, f) represent the mean; each data point represents an individual mouse; P values by Mann-Whitney test. g, Kaplan-Meier survival curve of mice from the indicated genotypes. P value by log-rank test. Numbers of mice (n) that were analysed per genotype in (c,e,f,g) are indicated in the graph

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