Extended Data Fig. 5: Adar+/Zα Ripk1EKO mice develop severe skin inflammation.
From: ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation
a, Macroscopic images of 21 day old Adar+/+ Ripk1EKO mice, Adar+/Zα Ripk1EKO mice and control littermates from 3 experiments. b, Kaplan-Meier plot of macroscopically visible lesion appearance of epidermis-specific RIPK1 knockout mice (Ripk1EKO) carrying heterozygous ADAR1 Zα domain mutant alleles (Adar+/Zα) or expressing wild type ADAR1. Littermate offspring containing two or one wild type Ripk1 alleles (Ripk1+/+, fl/+) or heterozygously expressing a functional Ripk1 allele in the epidermis (Ripk1EHZ) did not develop lesions and are shown as controls. Numbers of mice (n) that were analysed per genotype are indicated in the graph. P value by log-rank test
