Extended Data Fig. 1: Genomic features of ctDNA and metastatic tissue whole genomes.

(a) Per-sample overview of genomic information (grouped by same-patient sample pairs). Figure content is otherwise identical to Fig. 1d. (b) Fragment-length distribution of plasma cell-free DNA (cfDNA) of nuclear (left) and mitochondrial (right) origin. (c) Structures of E26 transformation-specific (ETS) family oncogenic fusions detected in the cohort. Solid colours denote intragenic regions of fusion partner genes (including untranslated regions) and lighter hues represent flanking intergenic 5’ upstream or 3’ downstream regions. The intergenic region between SLC45A3 and ELK4 is shown in grey. (d) Box plots illustrating higher microhomology-containing deletion counts (deletion length 3–5 bp with at least 2 bp of microhomology) (left) and structural variant counts (right) in samples with BRCA2 defects relative to wild-type (WT) samples.