Extended Data Fig. 9: Data supporting Fig. 3.
From: PI3K drives the de novo synthesis of coenzyme A from vitamin B5
a, Fractional abundance (M+4/total) of labelled metabolites in main Fig. 3c. Replicate samples (○). Mean (bars). SEM (error bars); n = 3 biological replicates. *significant difference from treatment marked (†), two-tailed student’s t-test, (pb, Fractional abundance (M+4/total) of labelled metabolites in main Fig. 3d. Replicate samples (○). Mean (bars). SEM (error bars); n = 3 biological replicates. *significant difference from treatment marked (†), two-tailed student’s t-test, (pc, Two-dimensional proliferation assay with PANK4 KO AKT+/+ MCF10A cells stably expressing empty vector or PANK4 (WT, T406A, or T406E) in serum-free media with serum replacement and growth factors over 4 days. Replicate samples (○). SEM (error bars); n = 3 biological replicates. *significant difference from treatment marked (†), one-way ANOVA with Tukey’s test, (p
