Extended Data Fig. 3: Validation of NR1 ablation. | Nature

Extended Data Fig. 3: Validation of NR1 ablation.

From: Dual action of ketamine confines addiction liability

Extended Data Fig. 3

a, Schematic of experimental details with virus injections and location of patch-clamp recordings. b, Representative traces of NMDA/AMPA recordings of NR1-KO (KO; sgGrin1) and control (CT; sgRosa26). Scale bar, 10 ms, 200 pA. c, NMDA/AMPA ratios (amplitudes measured for NMDA component 20 ms after the peak at +40 mV and AMPA component at −70 mV) of VTA GABA neurons from KO and CT mice. n (cells) = 6 (KO) and 6 (CT). Data are represented as mean ± SEM. *P < 0.05.

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