Extended Data Fig. 9
From: Secreted fungal virulence effector triggers allergic inflammation via TLR4
(a) Quantification of lung eosinophils in WT or Tlr4–/– mice infected for 10 days with 5x104 CFU C. neoformans. (b) Lung CFUs from Tlr4–/– or Tlr4–/– mice infected with wild type C.n. (5x104 CFU) for 10 days (c) FACS quantification of lung eosinophils in WT (N = 6 mice) or Tlr4–/– (N = 4 mice) mice sensitized intranasally with rCPL1. (d) Model of how secreted CPL1 modulates the macrophage inflammatory state (created using Biorender.com). p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001 by one-way ANOVA with Bonferroni test.
