Fig. 6: Activation of BAT by exposure to mild cold in healthy individuals and a patient with cancer.
From: Brown-fat-mediated tumour suppression by cold-altered global metabolism
a, Representative PET images of 18F-FDG uptake in healthy male volunteers under thermoneutral (28 °C) and cold exposure (16 °C) conditions for 2 weeks. n = 3 individuals. Scale bars, 100 mm. b, Representative PET images of 18F-FDG uptake in the bilateral areas of supraclavicular, cervical and parasternal regions in a patient with Hodgkin’s lymphoma under warm and mild cold conditions. Scale bars, 100 mm. c, Representative images by CT scanning in the tumour region under warm conditions and exposure to mild cold. Scale bars, 100 mm (top) and 50 mm (bottom). d, PET images of 18F-FDG uptake of the tumour region under warm and mild cold conditions. Scale bars, 50 mm. Arrows indicate respective positive signals. e, Quantification of SUV-BW positive signals shown in b. n = 3 separate scans. f, Quantification of SUV-BW positive signals shown in d. n = 3 separate scans. For e and f, data are mean ± s.e.m. Statistical analysis was performed using two-sided unpaired t-tests (e and f).
