Extended Data Fig. 11: De novo production of catharanthine and vindoline in fed-batch cultivations.
From: A microbial supply chain for production of the anti-cancer drug vinblastine
a. De novo vindoline production by MIA-CW-1 and MIA-EM strain series in BioLector Pro (1 mL) fed-batch cultivations. b. De novo vindoline and catharanthine production by fed-batch cultivations of strain MIA-EM-2 in ambr®250 bioreactors. The blue arrow in the catharanthine panel indicates the start of galactose induction. Data presented are all replicates (dots), and mean (square box) ± s.d. (n = 4).
