Fig. 4: De novo synthesis of strictosidine, tabersonine, vindoline and catharanthine in engineered yeast strains. | Nature

Fig. 4: De novo synthesis of strictosidine, tabersonine, vindoline and catharanthine in engineered yeast strains.

From: A microbial supply chain for production of the anti-cancer drug vinblastine

Fig. 4

Strains MIA-CM-3 and MIA-CR-A were grown in 96-well deep plates containing 0.5 ml of SC medium. Strain MIA-CW-1 was grown in a 24-well deep plate (2 ml). Strain MIA-EM-1 was grown in a 48-well BioLector Pro flower-shaped plate (1 ml) with continuous feeding of glucose (fed-batch). Data represented are mean ± s.d. (n = 3–4). C. roseus catharanthine synthase, CroCS.

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