Fig. 1: Identifying genetic variants that influence stroke risk.
From: Stroke genetics informs drug discovery and risk prediction across ancestries
Ideogram showing 89 genome-wide significant stroke-risk loci. The shapes correspond to ancestry: circles, cross-ancestry (CROSS-ANC); diamonds, Europeans (EUR); triangles, East Asians (EAS); squares, African Americans (AFR) or South Asians (SAS). Colours correspond to stroke types: green, AS; red, AIS; light blue, SVS; dark blue, CES; purple, LAS. The nearest genes to lead variants are displayed. Loci are characterized as follows, on the basis of replication results (Methods): bold with asterisk, high confidence; bold without asterisk, intermediate confidence; not bold, low confidence; underlined, loci identified in secondary MR-MEGA and MTAG analyses. Black and grey font indicate new and known loci, respectively. The numbers at the top indicate the chromosome.
