Extended Data Fig. 5: Sequence alignment of glycoprotein hormones and related receptors.
From: Hormone- and antibody-mediated activation of the thyrotropin receptor
a, Sequences alignment of human TSHR, LHCGR and FSHR in the region of the hormone-binding domain. Residues interact with TSH are labelled in light sea green and blue, while residues that determine TSH–TSHR specificity are labelled in light sea green. b, Sequences alignment of human TSHR, LHCGR and FSHR in the region of the P10 fragments. P10 is shown in orange. c, Sequences alignment of human TSH, CG and FSH β subunit. The major interface of TSHβ interacted with TSHR are highlighted in red, while residues that determine TSH–TSHR specificity are labelled in yellow. d, The α-subunit sequence of glycoprotein hormones. Structure resolved N-linked glycans are highlighted with red stars.
