Extended Data Fig. 9: A conserved ECD–TMD configuration for TSHR activation.
From: Hormone- and antibody-mediated activation of the thyrotropin receptor
a, Structure comparison of TSH–TSHR–Gs complex with M22ScFv–Gs complex. The ECD–TMD interface in two structures are shown. P10 in the TSH–TSHR–Gs complex is shown in blue. b, The two conserved disulfide bonds from the TSHR ECD–TMD interface, which are shown in yellow sticks. c, Detail interactions between ECL1 and I281, Y279 residues. d, The EM density of P10 from the TSH–TSHR–Gs complex. The density map is shown at a level of 0.076. e–g, Detail interactions between P10 and TSHR TMD.
