Extended Data Fig. 4: Effects of mutations in the cholesterol-binding motifs on the activation potency of TSH and ML-109 to TSHR. | Nature

Extended Data Fig. 4: Effects of mutations in the cholesterol-binding motifs on the activation potency of TSH and ML-109 to TSHR.

From: Hormone- and antibody-mediated activation of the thyrotropin receptor

Extended Data Fig. 4

a, Cholesterol binding sites in the TSHR structure. b, The representative concentration-response curves of TSH- and ML-109-induced WT and mutated TSHR activation. For cAMP analysis, data were shown as mean ± S.E.M. from three independent experiments (n = 3), performed in triplicates. Statistical significance of differences between WT and mutants was determined by two-sided one-way ANOVA with Tukey test. UD, undetectable.

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