Extended Data Fig. 9

(A) The restoring force f(S) is plotted versus the DPD output S. (B) Waddington’s landscape in the absence of the signaling driving force. The basins of attraction for differentiation and proliferation are colored blue and red, respectively. (C) Schematic diagram of the generation of cell fate decisions by the driving signaling force, which drives cell state changes, and the restoring force, which stabilizes a given cell state.