Extended Data Fig. 5: CDK11 inhibition alters transcription dynamics.
From: CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1
a, Metagene analyses of P-Ser2 ChIP-seq occupancies over 7500 genes. See Extended Data Fig. 4b for legend. b, c, Metagene analyses of P-Ser2 ChIP-seq occupancies over down-, up- and non-regulated genes in RNA-seq (b) and over transcripts with indicated lengths (c) upon 30 nM OTS964 or control DMSO treatment in HCT116 cells for 4 h. d, IGV gene tracks for gene Cdc25a and Riok3 showing RNAPII, P-Ser2, P-Ser5 and P-Ser7 ChIP-seq occupancies in control DMSO and OTS964 treated HCT116 cells for 4 h.
