Extended Data Fig. 10: FK-Prostetin is a FKBP12-dependent MAP4K4(HGK) kinase inhibitor.
From: Brain-restricted mTOR inhibition with binary pharmacology
a, Chemical structures of Prostetin and FK-Prostetin. b, Inhibition of MAP4K4(HGK) kinase activity by Lapatinib and FK-Lapatinib in the absence or presence of supplemented 10 µM recombinant FKBP12 protein (n = 2, data are presented as individual points).
