Extended Data Fig. 4: A RapaBlock analog with impaired binding to FKBP12 failed to block RapaLink-1 in cells.
From: Brain-restricted mTOR inhibition with binary pharmacology
a) Structures of RapaBlock and RapaBlock ethyl oxime. b) RapaBlock ethyl oxime shows attenuated affinity to FKBP12 (n = 3, data are presented as mean values +/− SD). c) RapaBlock ethyl oxime is less potent at blocking RapaLink-1. Data is representative of two independent experiments. For gel source data, see Supplementary Fig. 1.
