Extended Data Fig. 8: Steric clash between AvrSr35 and Sr35 NBD mediates Sr35 receptor activation.
From: A wheat resistosome defines common principles of immune receptor channels
Inactive Sr35 inside the cell comes in contact with Pgt effector AvrSr35. In avoidance of a steric clash (red) between AvrSr35 and the Sr35 NBD domain, the Sr35 NBD domain is forced to structurally rearrange and a ‘primed’ receptor-effector complex is formed. Full activation and oligomerization requires subsequent ADP release, ATP binding and, NOD module rearrangement and coiled-coil (CC) domain structural rearrangement. Sr35 domains and AvrSr35 are coloured according to in-figure legend.
