Extended Data Fig. 4: Details of EDIVD and R-cluster.
From: A wheat resistosome defines common principles of immune receptor channels
a, Multiple protein sequence alignment of HvMLA10, HvMLA13, Sr35 and ZAR1. Amino acids highlighted in red and in red text are identical and possess similar properties, respectively. Alignment of the EDIVD motif and arginine cluster are boxed in black (Robert and Gouet 2014). b, Electrostatic surface charge of Sr35 LRR around the EDVID motif. c, Structural alignment of Sr35 inactive structure prediction (cyan) and one protomer (yellow) from Sr35 resistosome. Detailed view of EDVID and arginine cluster interactions. In analogy to ZAR1, the Sr35 coiled-coil (CC) α1-helix might undergo structural rearrangement, which likely requires EDVID with arginine cluster interactions to transiently resolve.
