Fig. 2: Genetic control of expression with eQTL.
From: Phenotypic plasticity and genetic control in colorectal cancer evolution
a, The number of genes with significant models for each data type. b, Distribution of regression coefficients (effect sizes) for each data type. c,d, Volcano plots highlighting selected genes significant for SCNA (c) and Mut eQTLs (d) (linear regression two-sided t-tests; Padj, FDR-adjusted P values). e, In comparison with non-synonymous mutations (NS), enhancer (Enh) mutations tended to have large effect sizes and a higher proportion of positive effect sizes. f, The proportion of subclonal mutations associated with detectable changes in cis gene expression was significantly lower than for clonal eQTL mutations. g, Visualization of Fisher’s exact tests showing that gene–mutation combinations were more likely to be eQTLs if they were associated with recurrent phylogenetic genes (genes found to have evidence of phylogenetic signal in at least three tumours) for subclonal mutations, and that this was not significant for clonal mutations. Phylo and Non-phylo indicate whether a gene had evidence of phylogenetic signal in the tumour in which the mutation was present. Two-sided Fisher’s exact tests, P values not corrected for multiple testing.
