Extended Data Fig. 2: CMS and CRIS classification heterogeneity.
From: Phenotypic plasticity and genetic control in colorectal cancer evolution
a, Stacked bar charts showing per-sample classification of CMS in each tumour. b, Stacked bar charts showing classification of CRIS in samples from each tumour. c, Heatmap based on data in (a,b) where colour indicates proportion of samples of a particular CRIS/CMS class. Associations between CMS and CRIS classes are apparent. d, Examination of the enrichment of genes respectively included CMS and CRIS classifications in gene Groups as defined in Fig. 1. Both CRIS and CMS genes are depleted in gene Groups 1&2 but are enriched in Group 4. 11,401 genes used in two-sided Fisher’s exact tests. Error bars represent 95% confidence intervals. e, CMS assignments per tumour, only samples which could be confidently classified (FDR < 0.05) are shown. f, As in (e) but for CRIS. g, Heatmap of centroid distances of each sample from CMS classes for tumour C550, black squares indicate the minimum (most likely) class for each sample, and stars represent significance of classification. h, As in (g) but for CRIS
