Extended Data Fig. 8: Transcriptional changes of genes nearby candidate loci in response to Y. pestis infection across cell types.
From: Evolution of immune genes is associated with the Black Death
For each cell type profiled using single-cell RNA sequencing, we show the effect of Y. pestis infection upon gene expression. A negative estimate (purple) indicates that the gene is downregulated and a positive value (red) indicates that the gene is up-regulated. The statistical support for the reported changes is given by the associated p values. Larger circle sizes represent smaller p values and empty circles refer to cases where the gene was not expressed in that cell type.
