Extended Data Fig. 5: AML-specific loops associated with sample-specific open chromatins and gene expression. | Nature

Extended Data Fig. 5: AML-specific loops associated with sample-specific open chromatins and gene expression.

From: Subtype-specific 3D genome alteration in acute myeloid leukaemia

Extended Data Fig. 5

a, Hi-C maps for the MEIS1 and ERG gene regions. Left lower halves are for AML samples and the right upper halves are for HSPC and PBMC. The loops are absent in all three PBMC samples (only one is plotted) and less frequent in the four HSPC samples (only one is plotted). b-c, RNA-Seq, CUT&Tag for H3K27ac and H3K27me3, and ATAC-Seq data for regions surrounding the three genes. Purple arcs indicate chromatin loops predicted in at least two AML samples. Shown in the figure are two representative AML samples.

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