Fig. 2: Structure of the SEAC core.
a, Structures of Sea4–Seh1, Sea2–Seh1 and Sea3–Sec13. Both Sea2 (left) and Sea3 (right) interact with Sea4 using the C-terminal RING domain. b, Zoomed-in view of the RING–RING interactions between Sea2 and Sea4 (top) or Sea3 and Sea4 (bottom). c, Structure of the Sea4–Seh1 core cage, formed by four copies of the Sea4–Seh1 dimer. Each dimer is numbered I to IV, and interactions between copies are indicated. d, Protomer-focused map coloured according to the subunits showing the interaction between Sea2 and Sea3, which links opposite non-interacting copies of Sea4–Seh1. e, Model of the SEAC core protomer showing the Sea3 lock, an extension in the Sea3 α-solenoid that ‘locks’ the Sea2 DIM.
