Extended Data Fig. 4: SEAC core subunits are coatomer-like proteins. | Nature

Extended Data Fig. 4: SEAC core subunits are coatomer-like proteins.

From: Cryo-EM structure of the SEA complex

Extended Data Fig. 4

a, Comparison of structures of Sea4, Sea3 and Sea2 with the AlphaFold predictions for their homologous GATOR2 subunits (Mios, Wdr59 and Wdr24). b, pLDDT score for different domains in GATOR2 subunit AlphaFold predictions. c, Structures of Nup85-Seh1 (PDB: 3f3f), Sec16-Sec13 (PDB: 3mzk) and Sec31-Sec13 (PDB: 2pm6). All of these subunits interact with the coatomer β-propeller through insertion of a seventh blade. d, Structures of Sea2-Seh1, Sea4-Seh1 and Sea3-Sec13. The domain invasion motif (DIM) of Sea2, Sea4 and Sea3 is shown with the corresponding cryo-EM density (protomer focused and Sea2-Sea3 focused maps). For Sea3, the N-terminal β-propeller was omitted for clarity.

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