Extended Data Fig. 5: (related to Fig 3): ILC2 deletion regulates myeloid and epithelial populations in the lung.
From: Non-redundant functions of group 2 innate lymphoid cells
a, Bubble plot of marker genes of global cell populations in single-cell RNA-sequencing of myeloid and epithelial cells in the steady state lung of Nmur1iCre-eGFP Id2fl/fl mice and littermates. b, Marker genes of subclusters of interstitial macrophages. c, Marker genes of DC subclusters. d, Marker genes in subclusters of alveolar type 2 epithelial cells. e—g, Subclusters in e macrophages, f dendritic cells and g alveolar type 2 epithelial cells. h, Macrophage UMAPs color-coded gray-to-red with genes downregulated in Macrophages of Nmur1iCre-eGFP Id2fl/fl mice. i, Macrophage UMAPs color-coded with genes upregulated in macrophages of Nmur1iCre-eGFP Id2fl/fl mice. j, DC UMAP color-coded by Ccl24 expression. k, UMAPs of alveolar type 2 epithelial cells color-coded with genes downregulated in alveolar type 2 epithelial cells in Nmur1iCre-eGFP Id2fl/fl mice. l, Statistical evaluation of genes displayed in f—h. Cells from four mice per group were pooled. Littermate controls for (a—l) were Id2fl/fl or Id2fl/+.
