Extended Data Fig. 5: L-R networks and feature summary of five TIMELASER subtypes.
From: Liver tumour immune microenvironment subtypes and neutrophil heterogeneity
a, Heatmap showing Ro/e enrichment values of TIMELASER-specific L-R pairs. b, Chord diagrams showing the interactions within each TIMELASER subtype mediated by specific L-R pairs. Line width is proportional to interaction intensity and coloured by TIMELASER subtypes. c, Barplots showing the number of ligand-receptor pairs significantly enriched in TIME-IA and TIME-ISM modules. d, Heatmap showing the expression of chemokines and the corresponding receptors in TIME-IA and TIME-ISM patients. Exp, normalized mean expression. e, Summary of key features across TIMELASER subtypes. f, Schematic for five TIMELASER subtypes. Selected cell populations are shown for each TIMELASER subtype with tumour cells as background. Tex, exhausted T cell; NK, nature killer cell; TAN, tumour-associated neutrophil; TAM, tumour-associated macrophage; DC, dendritic cell.
