Extended Data Fig. 8: Cryo-EM data processing of hSLC19A1 bound to 5-MTHF. | Nature

Extended Data Fig. 8: Cryo-EM data processing of hSLC19A1 bound to 5-MTHF.

From: Recognition of cyclic dinucleotides and folates by human SLC19A1

Extended Data Fig. 8

a, Representative raw micrograph of hSLC19A1-Fab-5-MTHF complex in nanodisc. b, Selected 2D class averages of hSLC19A1-Fab-5-MTHF complex particles. c, Data processing flow chart. d, Gold-standard Fourier shell correlation curves of the final reconstruction. e, Local resolution distribution of hSLC19A1-Fab-5-MTHF complex. f, Chemical structure of 5-MTHF. g, Cryo-EM densities of 5-MTHF at 8σ.

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