Fig. 1: Susceptible mice show social reward impairment after CSDS in both males and females.
From: Social trauma engages lateral septum circuitry to occlude social reward
a, Experimental timeline for social behaviour tests following chronic social defeat. b,g, SI ratios of females (one-way analysis of variance (ANOVA) with Tukey’s multiple-comparisons test, F (2, 31) = 53.96, P < 0.0001, n = 10 (CTRL), 12 (RES), 12 (SUS) (b); and of males (one-way ANOVA, F (2, 46) = 24.36, P < 0.0001, n = 10 (CTRL), 13 (RES), 26 (SUS) (g). c,h, Social investigation time from RI test of females (one-way ANOVA, F (2, 31) = 6.755, P = 0.0037) (c); and of males (F (2, 46) = 14.82, P < 0.0001) (h). d,i, Social avoidance of females (F (2, 31) = 33.13, P < 0.0001) (d) and males (F (2, 46) = 15.37, P < 0.0001) (i). e, Time spent in paired and unpaired chambers during sCPP test (female CTRL (two-way repeated-measures ANOVA followed by Å Ãdák’s multiple-comparisons test, F (1, 18) = 7.023, P = 0.0163, n = 10); RES mice (F (1, 22) = 4.598, P = 0.0433, n = 12); and SUS mice (F (1, 22) = 0.08155, P = 0.7779, n = 12)). f, Correlation between SI ratio and sCPP in females (R2 = 0.1474, P = 0.025). j, Time spent in paired and unpaired chambers during sCPP test (two-way repeated-measures ANOVA: male CTRL (F (1, 18) = 6.074, P = 0.0240, n = 10); RES mice (F (1, 26) = 7.499, P = 0.0110, n = 13); and SUS mice (F (1, 50) = 0.4818, P = 0.4908, n = 26)). k, Correlation between SI ratio and sCPP in males (R2 = 0.08939, P = 0.0369). NS, not significant. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. All data expressed as mean ± s.e.m.
