Extended Data Fig. 2: Memory tests in animals exposed to CSDS, effects of reversed test order on social behaviours, and behavioural parameters grouped by CPP score.
From: Social trauma engages lateral septum circuitry to occlude social reward
a, Schematic diagram of novel object recognition (NOR) test and novel location test (NLT). b, Novel object investigation time (One-Way ANOVA, F (2, 29) = 3.041, P = 0.0633, n = 10 (CTRL), 9 (RES), 13 (SUS)) and c, novel location investigation time (One-Way ANOVA F (2, 29) = 0.5601, P = 0.5772). d, Schematic diagram of reversed behaviour test order. e, Subtracted CPP score (One-Way ANOVA, F (2, 22) = 3.984, P = 0.0334), social investigation time (F (2, 22) = 8.267, P = 0.0021), social avoidance (F (2, 22) = 9.919, P = 0.0008) and SI ratio (F (2, 22) = 18.32, P < 0.0001, n = 8 (CTRL), 7 (RES), 9 (SUS). f, g, Social behavioural parameters after grouping by CPP score, (f) females, SI ratio (two-tailed t-test, t = 1.660, df = 32, P = 0.1067), social investigation time (t = 3.788, df = 32, P = 0.0006), social avoidance (t = 3.001, df = 32, P = 0.0052), latency (t=3.204, df = 32, P = 0.0031), n = 11 (CPP-), 23 (CPP+). (g) males, SI ratio (two-tailed t-test, t = 2.298, df = 47, P = 0.0261), social investigation time (t=2.868, df = 47, P = 0.0062), social avoidance (t = 2.545, df = 47, P = 0.0143), latency (t = 1.438, df = 47, P = 0.1570), n = 21 (CPP-), 28 (CPP+). ns, not significant, * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001. All data are expressed as mean ± s.e.m.
