Extended Data Fig. 7: Single-cell Omics reveals unique regulatory networks in transitional progenitor-like subpopulations in G3 and G4 MBs.
From: RETRACTED ARTICLE: Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis
a,b, Heatmaps of scaled accessible peak-to-gene links identified along the integrated pseudotime trajectory from a) TCP-like to G3 MB, and b) TCP-like to G4 MB subclusters. Enriched transcription factor motifs are also shown. c, Dot plot showing positive transcriptional regulators identified in the TCP-like cells from G3 and G4 MB compared to other tumor subclusters. x-axis, the correlation of TF motif enrichment to TF gene expression. y-axis, ΔTF deviation scores between TCP-like cells and other subclusters. d, Tn5 bias-adjusted footprints for transcription factors SOX11 in TCP-like populations, MYC and OTX2 in G3 MBs, and LMX1A and RORA in G4 MBs. e, f, Genome accessibility track visualization of marker genes with peak co-accessibility in (e) TCP-G3-like cells in G3 MB (OTX2 and HLX) and (f) TCP-like cells in G4 MB (BARHL1 and PAX6).
