Extended Data Fig. 4: Trajectory analysis of human MB tumor cells.
From: RETRACTED ARTICLE: Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis
a, CIBERSORTx deconvolution analyses of human fetal cerebellar populations against bulk transcriptomes of human MB subgroups from CBTTC cohort. b—d, Population, marker gene expression, and trajectory analysis of human MB tumours in G3 MBs (b, n = 52,743 cells), G4 MBs (c, n = 43,643 cells) or SHH MBs (d, n = 21,342 cells) using Vector based on the UMAP images. e—h, Reference map (e) of human fetal cerebellar neural progenitor cells based on the ProjecTILs profile. MYC+ G3 MB (f), G4 MB (g) and SHH MB(h) tumor cells were projected onto the reference map. i, Predicted fraction of cells in human MB subgroup CBTTC cohorts using CIBERSORTx deconvolution using SHH, G3 and G4 MB tumor cell type as reference.
