Extended Data Fig. 4: Unsupervised matching analysis of MitCOM protein profile segments.
From: Mitochondrial complexome reveals quality-control pathways of protein import
a, Histogram of similarity scores obtained for the segments of the abundance–mass profiles of MitCOM proteins (total of 1.2 × 109 values). The scores integrate (i) correlation of the profile segments of any MitCOM protein with those from all MitCOM proteins (local Pearson correlation, Extended Data Fig. 3c), (ii) ratio of their molecular abundance and (iii) distance of their maxima (see Methods); a value of 1.0 indicates perfect agreement of all three parameters. Pairs in groups of protein profile peaks shown in the figures and/or selected for biochemical verification experiments had score values between 1.0 − 0.88 (highlighted in red). b, Pairs of protein profile segments (indicated by the slice numbers given in brackets) exhibiting best similarity scores (‘simscore’) of the proteins highlighted and/or used for further experiments in the indicated figures.
