Extended Data Fig. 7: Cell clusters in the jugular lymph sacs of Prox1 enhancer mutant mice express range of hematopoietic and endothelial markers.
From: A Prox1 enhancer represses haematopoiesis in the lymphatic vasculature

a, Coronal sections of E14.5 mutant embryos illustrating cells within clusters budding from PROX1+ LYVE1+ CD31+VECAD+ lymphatic endothelium are heterogenous in identity and are variously positive for RUNX1, cKIT, CD45, GATA2 and CD34. Data are representative of clusters observed in 7 of 15 embryos analyzed at E14.5. b, Rare, small clusters were also observed budding from the jugular lymph sacs of wildtype embryos at E14.5. These clusters are positive for RUNX1, cKIT and CD45. A CD45+ VECAD+ PROX1+ cell is indicated (arrow). Data are representative of two independent embryos. JLS, jugular lymph sac. Scale bars, 50 µm.