Fig. 1: Capturing the SARS-CoV-2 RTC ternary complex.
From: Structural basis for substrate selection by the SARS-CoV-2 replicase
a, Schematic depicting the major steps of the nucleotide addition cycle of the RTC. The pre-incorporation complex studied here is highlighted (red dashed box). b, nMS analysis of the RTC bound to a 3′ oxy p-RNA in the absence and presence of 300 µM ATP, RDV-TP or GTP, respectively. c, Similar nMS analysis to b but the RTC was reconstituted using a 3′-deoxy p-RNA (RTC*). p-RNA and t-RNA schematics were created with BioRender.com.
