Fig. 3: Single-cell populations and neighbourhoods are associated with distinct outcomes in LUAD.
From: Single-cell spatial landscapes of the lung tumour immune microenvironment
a–c, t-SNE of endothelial, myeloid and lymphoid cell populations highlighting the distribution of 108,387 endothelial cells (a), 42,427 neutrophils (b) and 147,980 CD4+ TH cells (c), and the positivity of the Ki-67 (endothelial cells), HIF1α (neutrophils) and pERK (TH cells) markers. Kaplan–Meier curves of overall survival for 416 patients with LUAD based on low (z-score < 0) and high (z-score ≥ 0) prevalence of the indicated cell types are also shown. d, Heatmap of 30 CNs discovered in 416 patients with LUAD. The CNs highlighted in grey refer to B-cell-enriched neighbourhoods. e, Kaplan–Meier curves of overall survival for 416 patients with LUAD based on low (z-score < 0) and high (z-score ≥ 0) prevalence of B cell CN11 (left) and CN25 (right). log-rank test was used for statistical analysis (a–c,e).
