Extended Data Fig. 8: M1-like MDM enriched cellular neighbourhoods are associated with survival in glioblastoma.
From: Single-cell spatial immune landscapes of primary and metastatic brain tumours
a, Heatmap depicting the cellular composition of glioblastoma cellular neighbourhoods (CN), with N = 10 nearest neighbours and CN = 30 neighbourhoods (n = 192 images). 6 CNs are enriched with >3000 M1-like MDM (grey highlight; number of M1-like MDM in each CN is indicated). Of these, 2 (red text) are associated with prolonged survival. Table shows P-values of survival analyses (Log-rank (Mantel-Cox) test) for samples based on median CN frequency. CN frequencies were averaged when multiple samples corresponded to the same patient. b, Cell frequency correlation graphs of neutrophils, M1-like MDM and M1-like MG. Linear regression with 95% confidence interval is shown.
