Extended Data Fig. 1: Crisis cells exhibit an inflammatory gene signature.
From: Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis
a, Heat maps representing RNA-sequencing data for DEGs between growing and crisis IMR90E6E7 and WI38SV40LT at the indicated PDs. DEGs with a fold change > 1.5 and false-discovery rate <0.05 are shown. One experiment was performed. b, Venn diagram of commonly upregulated DEGs (n = 1,490) in crisis of IMR90E6E7 and WI38SV40LT as compared with growing cells. c, Graphical representation of the enrichment of gene ontology terms for commonly upregulated DEGs (n = 1,490) in crisis. The top 20 biological processes are shown. Abbreviations: DEGs: differentially expressed genes; GO: gene ontology; PDs: population doublings.
