Extended Data Fig. 2: snCv3 marker genes and comparison with reference data.
From: An atlas of healthy and injured cell states and niches in the human kidney
a. Dot plot showing averaged marker gene expression values (log scale) and proportion expressed for snCv3 clusters. b. Cell type labels predicted from Lake et. al. 201912 mapped on the snCv3 UMAP embedding. Inset shows the corresponding prediction score values. c. UMAP of Lake et. al. 201912 data mapped to snCv3 embeddings showing subclass level 3 predicted labels. Inset shows the corresponding prediction score values. d. UMAP of Muto et al. 202115 data mapped to snCv3 embeddings showing subclass level 3 predicted labels. Inset shows the corresponding prediction score values. e. Heatmap showing correlation of averaged scaled gene expression values for snCv3 epithelial (reference state) clusters and mouse bulk segmental RNA-seq data from Chen et al., 202161. f. Heatmap showing correlation of averaged scaled gene expression values for snCv3 distal tubule clusters (reference states) and mouse scRNA-seq data from Chen et al., 202161. g. Heatmap showing correlation of averaged scaled gene expression values for snCv3 clusters (reference and altered/adaptive states) and mouse snRNA-seq clusters from Kirita et al., 20204. h. Heatmap showing correlation of averaged scaled gene expression values (reference states) for snCv3 clusters and mouse scRNA-seq clusters from Ransick et al., 201959. i. Heatmap showing correlation of averaged scaled gene expression values for snCv3 stromal clusters (reference and altered/adaptive states) against human scRNA-seq clusters from Kuppe et al., 202025. j. Heatmap showing correlation of averaged scaled gene expression values for snCv3 immune cell clusters and mouse immune cell types from Immgen.org. k. Heatmap showing correlation of averaged scaled gene expression values for snCv3 immune cell clusters and human immune cell types from Monaco et al. 201962. l. UMAP of Stewart et al., 201914 immune single-cell RNA-seq data mapped to snCv3 embeddings showing subclass level 3 predicted labels (top) and the prior published cell type annotations (bottom). Inset shows the corresponding prediction score values.
