Extended Data Fig. 2: Effect of PM in multiple mouse models of lung cancer.

A) Schematic of PM exposure and representative huEGFR^L858R IHC of ET mice induced with AT2-specific Ad5-SPC-Cre exposed to PM or PBS control and quantification of neoplastic lesions (n = 14 PBS, n = 11 PM). Mann-Whitney test. B) Schematic of PM exposure followed by induction of EGFR^L858R and quantification of precancerous lesions/mm² of lung tissue (n = 9 PBS; n = 7 5 μg; n = 11 50 μg PM). One-way ANOVA. C) Schematic of PM exposure and representative H&E of a lung adenocarcinoma in a 50 μg PM exposed, doxycycline treated CCSP-rtTa; TetO-EGFR^L858R mice; quantification of number of adenocarcinomas per mouse below (n = 9 per group). One-way ANOVA. D) Schematic of PM exposure and representative IHC for red fluorescent protein (RFP, marks tdTomato+ cells) in Rosa26^{LSL-tdTomato/+};Kras^LSL-G12D/+ mouse model in control or 50 μg PM exposed conditions; quantification of number of hyperplastic lesions per mouse (n = 9 control, n = 9 5 μg and n = 12 50 μg). One-way ANOVA. Scale bar 50 μm (C main), 20 μm (C insert), 100 μm A & D.

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